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- Title
Two-year results of reduced-fluence photodynamic therapy combined with intravitreal ranibizumab for typical age-related macular degeneration and polypoidal choroidal vasculopathy.
- Authors
Yoshida, Yusaku; Kohno, Takeya; Yamamoto, Manabu; Yoneda, Tasuku; Iwami, Hisashi; Shiraki, Kunihiko
- Abstract
Purpose: To report the 2-year results of reduced-fluence photodynamic therapy (RF-PDT) combined with intravitreal ranibizumab (IVR) for typical age-related macular degeneration (AMD) and polypoidal choroidal vasculopathy (PCV). Methods: Twenty-four previously untreated eyes of 23 AMD patients with decimal best-corrected visual acuity (BCVA) of less than 0.7 received the combined therapy, followed by retreatments as needed over the subsequent 2 years. When the BCVA was better than or equal to 0.7, only 3 monthly IVR injections were performed during the retreatment. Results: The BCVAs were maintained in 7 of 10 typical AMD eyes and in 13 of 14 PCV eyes at month 24. The mean BCVA improved in the PCV group ( P < 0.05) but not in the typical AMD group. The central foveal thickness decreased in both groups ( P < 0.01, P < 0.001). The mean numbers of the total PDT and IVR injections were 1.8 and 7.2 in the typical AMD group and 1.8 and 6.4 in the PCV group. Conclusion: After RF-PDT combined therapy with administration of retreatments as needed that consisted of either 3 IVR injections alone or combined therapy, the BCVA was maintained in typical AMD and improved in PCV during a 2-year follow-up period.
- Subjects
RETINAL degeneration; DISEASES in older people; PHOTOCHEMOTHERAPY; VISUAL acuity; RETINAL diseases
- Publication
Japanese Journal of Ophthalmology, 2013, Vol 57, Issue 3, p283
- ISSN
0021-5155
- Publication type
Article
- DOI
10.1007/s10384-013-0234-z