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- Title
Effect of Pregabalin in the Treatment of Refractory Neck Pain: Cost and Clinical Evidence from Medical Practice in Orthopedic Surgery and Rehabilitation Clinics.
- Authors
Flórez-García, Mariano; Ceberio-Balda, Félix; Morera-Domínguez, Carles; Masramón, Xavier; Pérez, María
- Abstract
Background: The study aims to prospectively analyze the effect of adding pregabalin upon costs and consequences in the treatment of refractory neck pain under routine medical practice. Methods: A secondary analysis was carried out including patients over 18 years, with 6-month chronic neck pain refractory from a prospective, naturalistic, 12-week two-visit study. The analysis compared patients adding pregabalin to its therapy vs. usual care. Severity of pain, healthcare resources utilization, lost workday equivalents (LWDE) because of pain, and related cost-adjusted reductions were assessed. Results: A total of 312 patients (65.3% women, age 54.2 [12.1] years), 78.2% receiving pregabalin, were analyzed. Adding pregabalin was associated with higher adjusted reduction in pain severity: -3.2 (1.8) points, 55.4% responders (3 50% baseline pain reduction) vs. -2.3 (2.0) and 38.2%, respectively; P < 0.001, yielding a higher reduction in mean LWDE: 20.1 (23.1) vs. 8.2 (22.4); P = 0.014, which produced significant reductions in the indirect components of cost: €1,041.0 (1,222.8) vs. €457.3 (1,132.1), P = 0.028. The costs of pregabalin (€309.8 [193.2] vs. €26.4 [79.6], P < 0.001) was offset by higher numerical reductions in the other components of costs, producing similar direct cost reductions in both groups at the end of the study: €66.8 (1,080.8) and €143.5 (1,922.4), respectively; P = 0.295. Conclusion: Compared with usual care, the addition of pregabalin to treat refractory neck pain seems to be associated with a higher reduction in pain severity and lost work-days equivalents, which in turn results in a greater reduction of the indirect components of cost while maintaining similar healthcare cost levels despite its higher price.
- Subjects
SPAIN; SICK leave; ANALGESICS; ANALYSIS of variance; CHI-squared test; CHRONIC pain; COMPUTER software; CONFIDENCE intervals; FISHER exact test; GABA; INTERVIEWING; LONGITUDINAL method; MEDICAL care use; MEDICAL care costs; MEDICAL cooperation; NECK pain; SCIENTIFIC observation; HEALTH outcome assessment; RESEARCH; RESEARCH funding; STATISTICAL sampling; SELF-evaluation; STATISTICS; T-test (Statistics); U-statistics; DATA analysis; SECONDARY analysis; TREATMENT effectiveness; SEVERITY of illness index; ECONOMICS
- Publication
Pain Practice, 2011, Vol 11, Issue 4, p369
- ISSN
1530-7085
- Publication type
Article
- DOI
10.1111/j.1533-2500.2010.00430.x