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- Title
磁共振成像弥散张量成像参数联合血清 NSE, Lp-PLA2 在脑梗死患者的 诊断和预后不良风险评估中的应用价值.
- Authors
赵 烨; 刘 超; 邓 能; 朱 坤; 柳 林
- Abstract
Objective: To explore the application value of magnetic resonance imaging(MRI) diffusion tensor imaging(DTI)parameters combined with serum neuron specific enolase(NSE) and lipoprotein-associated phospholipase A2(Lp-PLA2) in the diagnosis and risk assessment of poor prognosis of patients with cerebral infarction. Methods: 106 patients with cerebral infarction who were admitted to China Japan Friendship Hospital of Jilin University from March 2021 to September 2022 were selected as cerebral infarction group, another 62 healthy volunteers who were underwent physical examinations during the same period were selected as control group,the DTI parameters, serum NSE and Lp-PLA2 levels were compared between two groups. 90d after discharge from cerebral infarction group, the assessment of prognosis by the modified Rankin scale(m RS), they were divided into good prognosis group and poor prognosis group, and the above indicators levels were compared between two groups. The value of DTI parameters combined with serum NSE and Lp-PLA2 for diagnosed cerebral infarction and predicted the prognosis of patients with cerebral infarction was analyzed by the receiver operating characteristic(ROC) curve. Results: The apparent diffusion coefficient (ADC) value and fractional anisotropy index(FA) value of cerebral infarction group were lower than those of control group (P<0.05), and the serum NSE and Lp-PLA2 levels were higher than those of control group(P<0.05). The FA value and ADC value of poor prognosis group were lower than those of good prognosis group(P<0.05), and the serum NSE and Lp-PLA2 levels were higher than those of good prognosis group(P<0.05). The area under the curve(AUC) for diagnosed cerebral infarction and predicted poor prognosis of patients with cerebral infarction by combined with FA value,ADC value, NSE and Lp-PLA2 were 0.852 and 0.874, respectively, and which were higher than individual diagnosed and predicted of each factor. Conclusion: The DTI parameters FA value and ADC value of cerebral infarction decrease, while serum NSE and Lp-PLA2levels increase, combine with DTI parameters and serum NSE and Lp-PLA2 detection has high value for the diagnosis and prognosis predict of cerebral infarction
- Subjects
DIFFUSION tensor imaging; MAGNETIC resonance imaging; CEREBRAL infarction; ENOLASE; PROGNOSIS
- Publication
Progress in Modern Biomedicine, 2023, Vol 23, Issue 23, p4463
- ISSN
1673-6273
- Publication type
Article
- DOI
10.13241/j.cnki.pmb.2023.23.012