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- Title
Folates and antifolates in rheumatoid arthritis.
- Authors
Jansen, Gerrit; Weijers, Karin; Blits, Marjolein; van der Heijden, Joost; Gent, Yoony; Al, Marjon; van der Laken, Conny; Molthoff, Carla; Verweij, Cor; Voskuijl, Alexandre; Lems, Willem; Scheper, Rik; Peters, Godefridus; Ratnam, Manohar; Aassaraf, Yehuda; Dijkmans, Ben
- Abstract
Almost all current standard treatment of care for patients with chronic inflammatory diseases such as rheumatoid arthritis (RA) includes the folate antagonist methotrexate (MTX). Despite the proven efficacy of MTX in RA treatment, it is anticipated that further improvement of antifolate-based therapies can be achieved by integrating the continuously extending knowledge of parameters underlying drug efficacy. Herein, an overview will be presented of strategies that may assist in the future design of rationalized and personalized targeted therapies with a folate antagonist. Issues that will be discussed include (i) early detection of arthritis, (ii) genomic studies of folate/MTX pathway genes for MTX response predictions, (iii) identification of MTX resistance modalities, (iv) exploration of second/third generation of antifolates which may substitute for MTX, and (v) folate (food) supplementation.
- Publication
Pteridines, 2013, Vol 24, Issue 1, p21
- ISSN
0933-4807
- Publication type
Article
- DOI
10.1515/pterid-2013-0012