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- Title
Deletion of the activating NKG2C receptor and a functional polymorphism in its ligand HLA-E in psoriasis susceptibility.
- Authors
Zeng, Xue; Chen, Haoyan; Gupta, Rashmi; Paz‐Altschul, Oscar; Bowcock, Anne M.; Liao, Wilson
- Abstract
Psoriasis is an inflammatory, immune-mediated disease of the skin. Several studies have suggested that natural killer ( NK) cells and their receptors may be important for its pathogenesis. Here, we examined whether deletion of the activating natural killer receptor gene NKG2C, which has a frequency of 20% in the European population, was associated with psoriasis susceptibility. The NKG2C deletion and a functional polymorphism in its ligand HLA-E were genotyped in a Caucasian cohort of 611 psoriasis cases and 493 controls. We found that the NKG2C deletion was significantly increased in cases compared with controls [0.258 vs 0.200, P = 0.0012, OR = 1.43 (1.15-1.79)]. The low-expressing HLA-E*01:01 allele was associated with psoriasis ( P = 0.0018), although this association was dependent on HLA-C. Our findings support a potential immunoregulatory role for NK cells in psoriasis and suggest the importance of future studies to investigate the contribution of NK cells and their regulatory receptors to the pathogenesis of psoriasis.
- Subjects
KILLER cells; CELL receptors; BINDING sites; PSORIASIS; SKIN diseases; GENETIC polymorphisms; LIGAND binding (Biochemistry); CYTOLOGY
- Publication
Experimental Dermatology, 2013, Vol 22, Issue 10, p679
- ISSN
0906-6705
- Publication type
Article
- DOI
10.1111/exd.12233