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- Title
"Fat Shadows" From DXA for the Qualitative Assessment of Lipodystrophy: When a Picture Is Worth a Thousand Numbers.
- Authors
Meral, Rasimcan; Jalal, Abdelwahab; Neidert, Adam H.; Oral, Elif A.; Ryan, Benjamin J.; Horowitz, Jeffrey F.; Malandrino, Noemi; Brown, Rebecca J.; Muniyappa, Ranganath; Akıncı, Barış
- Abstract
<bold>Objective: </bold>Lipodystrophy syndromes are a heterogeneous group of disorders associated with selective absence of fat. Currently, the diagnosis is established only clinically.<bold>Research Design and Methods: </bold>We developed a new method from DXA scans called a "fat shadow," which is a color-coded representation highlighting only the fat tissue. We conducted a blinded retrospective validation study to assess its usefulness for the diagnosis of lipodystrophy syndromes.<bold>Results: </bold>We evaluated the fat shadows from 16 patients (11 female and 5 male) with generalized lipodystrophy (GL), 57 (50 female and 7 male) with familial partial lipodystrophy (FPLD), 2 (1 female and 1 male) with acquired partial lipodystrophy, and 126 (90 female and 36 male) control subjects. FPLD was differentiated from control subjects with 85% sensitivity and 96% specificity (95% CIs 72-93 and 91-99, respectively). GL was differentiated from nonobese control subjects with 100% sensitivity and specificity (95% CIs 79-100 and 92-100, respectively).<bold>Conclusions: </bold>Fat shadows provided sufficient qualitative information to infer clinical phenotype and differentiate these patients from appropriate control subjects. We propose that this method could be used to support the diagnosis.
- Subjects
LIPODYSTROPHY; MIXED ability grouping (Education); DISEASES; FAT; PATIENTS; DIAGNOSIS; ADIPOSE tissues; COMPARATIVE studies; RESEARCH methodology; MEDICAL cooperation; RESEARCH; RESEARCH funding; SYNDROMES; EVALUATION research; RETROSPECTIVE studies; PHOTON absorptiometry
- Publication
Diabetes Care, 2018, Vol 41, Issue 10, p2255
- ISSN
0149-5992
- Publication type
journal article
- DOI
10.2337/dc18-0978