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- Title
Regulation of human endometrial stromal decidualization by macrophage colony-stimulating factor.
- Authors
Tanaka, Tetsuji; Sakamoto, Tomoko; Umesaki, Naohiko; Ogita, Sachio; Tanaka, T; Sakamoto, T; Umesaki, N; Ogita, S
- Abstract
Decidualized human endometrial stromal cells and human decidual CD56+ cells are reported to produce macrophage colony-stimulating factor (M-CSF), although its physiological roles remain unclear. In this study, the effects of M-CSF on cell viability and 8-Br-cAMP-stimulated decidualization of normal human endometrial stromal cells are examined by using an in vitro decidualization activity assay system. M-CSF alone affected neither the viable cell numbers nor PRL release of nonstimulated stromal cells, while high concentrations of M-CSF strongly suppressed the viable cell numbers and PRL secretion of stromal cells costimulated with 8-Br-cAMP and M-CSF. However, M-CSF did not suppress the viable cell numbers and PRL secretion of 8-Br-cAMP-induced decidualized cells. These results indicate that high concentrations of M-CSF can suppress the cell viability of stromal cells in the decidualization process, and inhibit decidualization of endometrial stromal cells. Thus, nonpregnant decidual M-CSF may autoregulate decidualization and the viable cell numbers of endometrial stromal cells in a paracrine manner.
- Publication
Gynecologic & Obstetric Investigation, 2001, Vol 51, Issue 2, p124
- ISSN
0378-7346
- Publication type
journal article
- DOI
10.1159/000052907