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- Title
Population pharmacokinetics of cefquinome in pigs.
- Authors
Zhao, D. H.; Zhang, C. Y.; Zhang, Z.; Liu, Z. C.; Liu, B. T.; Yu, J. J.; Guo, J. P.; Deng, H.; Liu, Y. H.
- Abstract
This study was performed in 145 pigs to develop a population pharmacokinetics ( PPK) model by i.m. administration of cefquinome (CEQ) at the dose of 2 mg/kg in the neck muscle. Serum physiological and biochemical parameters for each pig were determined before administration. After administration, 2-4 samples were collected at random, with the sampling point evenly distributed in the three periods (<1 h, 1-4 h and >4 h). The plasma concentration of CEQ was determined by high performance liquid chromatography with UV detector. The pharmacostatistical analyses of concentration-time data, weight, age, gender, serum physiological and biochemical parameters were performed with nonlinear mixed effect modeling ( NONMEM). A one-compartmental model with first-order absorption and elimination adequately described the data from the study group. The optimal random effect model of pharmacokinetics parameters was of log-normal distribution and the residual errors assumed a mixed-type model (proportional and additive) to best explain intra-individual variability. Covariate analysis showed that body weight is positively correlated with apparent volume of distribution ( V/ F) and body clearance (CL/ F). The typical PPK parameters of Ka, CL, and V were 0.564/h, 5.15 L/h, and 1.36 L, respectively.
- Subjects
PHARMACOKINETICS; LABORATORY swine; CEPHALOSPORINS; HIGH performance liquid chromatography; RANDOM effects model
- Publication
Journal of Veterinary Pharmacology & Therapeutics, 2013, Vol 36, Issue 4, p313
- ISSN
0140-7783
- Publication type
Article
- DOI
10.1111/jvp.12026