We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Early manifestations and spectrum of recipient twin cardiomyopathy in twin-twin transfusion syndrome: relation to Quintero stage.
- Authors
Michelfelder, E.; Gottliebson, W.; Border, W.; Kinsel, M.; Polzin, W.; Livingston, J.; Khoury, P.; Crombleholme, T.
- Abstract
<bold>Objectives: </bold>To examine cardiac structural and functional changes in twin-twin transfusion syndrome (TTTS), relative to Quintero stage, as a means of evaluating the spectrum of cardiomyopathy in TTTS. <bold>Methods: </bold>This was a cross-sectional, retrospective study of 42 consecutive cases of TTTS referred to a single fetal therapy center. Quintero stages were assigned by standard criteria. Presence of ventricular hypertrophy, cardiomegaly, atrioventricular valve regurgitation (AVVR), ventricular systolic dysfunction and right ventricular outflow tract obstruction on fetal echocardiography were noted. The Doppler myocardial performance index (MPI), an index of global ventricular function, was calculated for both ventricles in subjects with adequate Doppler data. We compared cardiac changes across Quintero stages. <bold>Results: </bold>There was no cardiomyopathy observed in donor twins. The majority of subjects presented at Quintero Stage I (n = 14), II (n = 14) or III (n = 11), with fewer at Stages IV (n = 2) or V (n = 1). As early as Quintero Stages I and II, a significant proportion of recipient twins had ventricular hypertrophy (17/28, 61%), AVVR (6/28, 21%) or quantitative abnormalities in either right (12/24, 50%) or left (14/24, 58%) ventricular function. Increasing prevalence of biventricular systolic dysfunction and cardiomegaly accompanied advancing Quintero stage. <bold>Conclusions: </bold>Changes in cardiac structure and function not reflected in Quintero staging occur in recipient twins early in the evolution of TTTS. Incorporation of cardiac findings into assessment of TTTS severity may prove useful in stratification of risk and treatment selection.
- Subjects
PREGNANCY complications; FETAL diseases; TWINS; CARDIOMYOPATHIES; SYNDROMES; DIAGNOSIS of fetal diseases; PRENATAL diagnosis
- Publication
Ultrasound in Obstetrics & Gynecology, 2007, Vol 30, Issue 7, p965
- ISSN
0960-7692
- Publication type
journal article
- DOI
10.1002/uog.5211