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- Title
Cell Surface Receptor Function of Amyloid Precursor Protein That Activates Ser/Thr Kinases.
- Authors
Murayama, Yoshitake; Takeda, Shizu; Yonezawa, Kazuyoshi; Giambarella, Ugo; Nishimoto, Ikuo; Ogata, Etsuro
- Abstract
Amyloid precursor protein (APP) has been shown to serve as a Go-coupled receptor in cell-free systems [Okamoto et al: J Biol Chem 1995;270:4205-4208]. However, it has not been known whether APP exerts intracellular signaling functions in living cells. In this study, we show that stimulation of APP by anti-APP antibody as well as by a mutation found in familial Alzheimer's disease results in activation of a specific set of mitogen-activated protein kinases in multiple vertebrate cells. We conclude that APP acts as a cell surface receptor of biological relevance that turns on specific Ser/Thr kinases, and suggest that the signaling function of APP is a potential target of familial Alzheimer's disease mutations. Copyright © 1996 S. Karger AG, Basel
- Publication
Gerontology, 1996, Vol 42, Issue S1, p2
- ISSN
0304-324X
- Publication type
Article
- DOI
10.1159/000213818