We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Admixture mapping of lung cancer in 1812 African-Americans.
- Authors
Schwartz, Ann G.; Wenzlaff, Angela S.; Bock, Cathryn H.; Ruterbusch, Julie J.; Chen, Wei; Cote, Michele L.; Artis, Amanda S.; Van Dyke, Alison L.; Land, Susan J.; Harris, Curtis C.; Pine, Sharon R.; Spitz, Margaret R.; Amos, Christopher I.; Levin, Albert M.; McKeigue, Paul M.
- Abstract
Lung cancer continues to be the leading cause of cancer death in the USA and the best example of a cancer with undisputed evidence of environmental risk. However, a genetic contribution to lung cancer has also been demonstrated by studies of familial aggregation, family-based linkage, candidate gene studies and most recently genome-wide association studies (GWAS). The African-American population has been underrepresented in these genetic studies and has patterns of cigarette use and linkage disequilibrium that differ from patterns in other populations. Therefore, studies in African-Americans can provide complementary data to localize lung cancer susceptibility genes and explore smoking dependence-related genes. We used admixture mapping to further characterize genetic risk of lung cancer in a series of 837 African-American lung cancer cases and 975 African-American controls genotyped at 1344 ancestry informative single-nucleotide polymorphisms. Both case-only and case–control analyses were conducted using ADMIXMAP adjusted for age, sex, pack-years of smoking, family history of lung cancer, history of emphysema and study site. In case-only analyses, excess European ancestry was observed over a wide region on chromosome 1 with the largest excess seen at rs6587361 for non-small-cell lung cancer (NSCLC) (Z-score = −4.33; P = 1.5 × 10−5) and for women with NSCLC (Z-score = −4.82; P = 1.4 × 10−6). Excess African ancestry was also observed on chromosome 3q with a peak Z-score of 3.33 (P = 0.0009) at rs181696 among ever smokers with NSCLC. These results add to the findings from the GWAS in Caucasian populations and suggest novel regions of interest.
- Subjects
LUNG cancer risk factors; CAUSES of death; ENVIRONMENTAL risk assessment; GENETIC disorders; DISEASE susceptibility; PHYSIOLOGICAL effects of tobacco; GENETIC polymorphisms; AFRICAN Americans
- Publication
Carcinogenesis, 2011, Vol 32, Issue 3, p312
- ISSN
0143-3334
- Publication type
Article
- DOI
10.1093/carcin/bgq252