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- Title
14α-Hydroxylation of steroids by mycelium of the mold fungus Curvularia lunata (VKPM F-981) to produce precursors for synthesizing new steroidal drugs.
- Authors
Andryushina, V.; Voishvillo, N.; Druzhinina, A.; Stytsenko, T.; Yaderets, V.; Petrosyan, M.; Zeinalov, O.
- Abstract
Five 14α-hydroxylated derivatives of androstane and pregnane steroids were obtained using mycelium of the mold fungus Curvularia lunata (VKPM F-981). The conditions for microbiological transformation of androst-4-en-3,17-dione that enabled its 14α-hydroxy analog to be obtained in yields up to 60% with substrate loading 6 g/L were determined. The 21-acetoxy analog of proligestone was synthesized from 14α-hydroxycortexolone that was formed simultaneously with hydrocortisone during hydroxylation of cortexolone by C. lunata. The resulting 14α- and 14α,21-hydroxysteroids could be used as precursors for the synthesis of new drugs.
- Subjects
STEROID drugs; HYDROXYLATION; STEROID synthesis; MYCELIUM; HYPHOMYCETES; CHEMICAL precursors; ANDROSTANE; PREGNANE
- Publication
Pharmaceutical Chemistry Journal, 2013, Vol 47, Issue 2, p103
- ISSN
0091-150X
- Publication type
Article
- DOI
10.1007/s11094-013-0905-6