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- Title
Formulation and evaluation of new nasal drop using Essential Oil of Black Mustard (Brassica nigra) for the Management of Bacterial Rhinosinusitis.
- Authors
Sharma, Harshit; Tomar, Diksha; Patel, Rakesh; Jain, Sanjay
- Abstract
Plants are very useful and utilized as medicine due to their medicinal properties. Medicinal plants are great significance to the health of individuals and communities. Rhino sinusitis is a significant health problem worldwide. It is an infection of the nasal passages and the paranasal sinus. Purpose of this research, to formulate the nasal drop by utilization of essential oil of black mustard (Brassica nigra) , which is used in the management of bacterial rhino sinusitis. Essential oil of mustard was isolated by simultaneous steam distillation and extraction. It contain 79.97% of allyl isothiocynate which is the main component of mustard essential oil which is responsible for very strong pungent odour which cause irritation on direct application in high concentration. Nasal drops were formulated containing different concentration of mustard essential oil and evaluated for its antimicrobial activity against Gram Positive bacteria (S aureus) and Gram Negative bacteria (E. coli). The essential oil has a broad-spectrum antimicrobial activity with inhibition zones in the range of 9.43-13.67 mm in the concentration range from 100-450μg/ml.
- Subjects
ESSENTIAL oils; MUSTARD; SINUSITIS; MEDICINAL plants; ANTI-infective agents
- Publication
International Journal of Pharmacy & Life Sciences, 2017, Vol 8, Issue 11, p45
- ISSN
0976-7126
- Publication type
Article