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- Title
Antinociceptive effect of extracts of Marrubium astracanicum Jacq. aerial parts.
- Authors
Kahkeshani, Niloofar; Gharedaghi, Milad; Hadjiakhoondi, Abbas; Sharifzadeh, Mohammad; Khanavi, Mahnaz
- Abstract
Objective: The genus Marrubium is used for treatment of joint pain, gout, stomach-ache and colic in Iranian Traditional Medicine. Marrubium astracanicum Jacq. (M. astracanicum) is a native species in the flora of Iran. The aim of this study was to evaluate the antinociceptive properties of various extracts of aerial parts of M. astracanicum. Materials and Methods: Antinociceptive activities of total hydroalcoholic extract (THE) and its n-hexane (non-polar) and residual partition (polar) fractions were analyzed using formalin test in mice. Morphine (5 mg/kg) and normal saline were used as positive and negative controls, respectively. Results: Intraperitoneal administration of THE (50, 100 and 200 mg/kg), non-polar fraction (200 mg/kg) and polar fraction (100 and 200 mg/kg), 30 min before formalin injection, caused significant analgesic activity in acute phase (0-5 min after formalin injection) of formalin test (p<0.05 as compared to control and p>0.05 in comparison with morphine). In chronic phase (15-60 min after formalin injection), non-polar and polar fractions (50, 100 and 200 mg/kg) showed significant analgesic activity (p<0.001 as compared to control and p>0.05 in comparison with morphine). Conclusion: Different extracts of M. astracanicum demonstrated antinociceptive activity that support the traditional usage of Marrubium genus for the treatment of arthritis, gout and other inflammatory diseases.
- Subjects
ANALGESICS; THERAPEUTIC use of plant extracts; MARRUBIUM
- Publication
Avicenna Journal of Phytomedicine, 2017, Vol 7, Issue 1, p73
- ISSN
2228-7930
- Publication type
Article