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- Title
Prostaglandin F<sub>2α</sub> produced by inducible cyclooxygenase may contribute to the resolution of inflammation.
- Authors
Colville-Nash, Paul R.; Gilroy, Derek W.; Willis, Dean; Paul-Clark, Mark J.; Moore, Adrian R.; Willoughby, Derek A.
- Abstract
Cyclooxygenase-2 may play a role in resolution of carrageenan-induced pleurisy in rats by generating anti-inflammatory prostanoids. Here, we show exudate prostaglandin F2α concentrations rise during resolution of this model. These were reduced by the selective cyclooxygenase-2 inhibitor NS-398, which exacerbated inflammation. Concomitant treatment with NS-398 and the synthetic FP receptor agonist fluprostenol reversed this exacerbation. This suggests prostaglandin F2α produced by cyclooxygenase-2 contributes to resolution of this inflammatory reaction.
- Subjects
CYCLOOXYGENASE 2; LABORATORY rats; PROSTANOIDS; INFLAMMATION; EICOSANOIC acid derivatives
- Publication
Inflammopharmacology, 2005, Vol 12, Issue 5/6, p473
- ISSN
0925-4692
- Publication type
Article
- DOI
10.1163/156856005774382616