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- Title
Lentiginous eruption in resolving psoriasis plaques during treatment with ixekizumab: a case report and review of the literature.
- Authors
María, Pablo Santa; Valenzuela, Fernando; Morales, Claudia; De la Fuente, Raul; Cullen, Roberto
- Abstract
We report the case of a 56-year old male with severe plaque psoriasis that was successfully treated with ixekizumab, a new anti interleukin (IL)-17 monoclonal antibody. During the first months of treatment he developed a lentiginous eruption in the sites of rapidly resolving plaques. Biopsy and immunohistochemistry reports showed elements of both lentigo and post-inflammatory hyper pigmentation. These findings, which have been increasingly described in anti-tumor necrosis factor alpha (TNFα) and anti IL-12/IL-23 therapy, may be explained by the down regulating effect of TNFα and IL-17 on pigmentation genes, which is very rapidly suppressed by ixekizumab, resulting in hyper pigmentation, and by the alteration of mesenchymal-epidermal interaction via keratinocyte growth factor during the inflammatory period, which results in the development of histopathological elements of lentigo.
- Subjects
SKIN diseases; ACNEIFORM eruptions; ECZEMA; KERATOSIS; DERMATOLOGY
- Publication
Dermatology Reports, 2017, Vol 9, Issue 2, p43
- ISSN
2036-7406
- Publication type
Article
- DOI
10.4081/dr.2017.7079