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- Title
Determination of COL1A1 rs1800012 Polymorphism Related to Ligament and Tendon Injury in Turkish Professional Bodybuilders: Experimental Research.
- Authors
YILMAZ, Özlem Özge; POLAT, Tolga; TACAL ASLAN, Beste; YÜKSEL, İpek; GÖÇÜCÜ, Kubilay; ZİLELİ, Raif; ULUCAN, Korkut
- Abstract
Objective: Athletic performance is affected by genetic and environmental factors. Bodybuilding has been increasing around the world in recent years and it is accepted that the factors affecting athletic performance are the most important influences to achieve success in bodybuilding. The aim of our study is to determine the distribution of COL1A1 rs1800012 polymorphism associated with ligament and tendon injuries due to muscle tears with weight training and to compare the results with sedentary individuals. Material and Methods: A total of 15 Turkish bodybuilders and 50 sedentary individuals as a control group participated in our study. DNA isolation from peripheral blood samples of athletes was performed using a commercial kit (Invitrogen, Van Allen Way Carlsbad, Calif., USA). Genotyping was done by real-time polymerase chain reaction. Results: GG genotype and G allele were higher in both bodybuilders and control groups. In addition, there was no statistically significant difference in terms of genotype and allelic frequency of the COL1A1 rs1800012 polymorphism between the bodybuilders and the control group. Conclusion: Our study is the first to examine the COL1A1 rs1800012 polymorphism in Turkish bodybuilders. Our results report that the TT genotype and T allele may be protective against ligament and tendon injuries, similar to the literature. We think that similar studies will guide future studies in terms of sports injuries and COL1A1 rs1800012 polymorphism.
- Subjects
TURKEY; SKELETAL muscle injuries; SPORTS injuries risk factors; WOUNDS &; injuries; RISK assessment; SEDENTARY lifestyles; BLOOD collection; BODYBUILDING; PHYSICAL training &; conditioning; TURKS; REVERSE transcriptase polymerase chain reaction; CHI-squared test; DESCRIPTIVE statistics; TENDON injuries; EXPERIMENTAL design; RESISTANCE training; CASE-control method; LIGAMENT injuries; DATA analysis software; COMPARATIVE studies; SINGLE nucleotide polymorphisms; GENOTYPES; ALLELES; DISEASE risk factors
- Publication
Turkiye Klinikleri Journal of Sports Sciences, 2024, Vol 16, Issue 1, p1
- ISSN
1308-0938
- Publication type
Article
- DOI
10.5336/sportsci.2023-97720