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- Title
Predicting ADME/Tox properties of hydroxytyrosol in the leaves of Olea europaea L.
- Authors
Suzhen Jiang; Xinghua Liu; Hongjian Yu; Shihong Li; Jingming Jia; Anhua Wang
- Abstract
In order to study the possibility of hydroxytyrosol (HT) as a drug, we used SwissADME system to predict ADME of HT and pkCSM system to predict Tox of HT. The results show that hydroxytyrosol meets the Lipinski's five principles of drug-like properties. With strong efficacy and pharmacological activity, HT has high drug-likeness degree. With good bioavailability, it can be easily absorbed by the gastrointestinal tract, though not absorbed by skin. Hydroxytyrosol has not only a strong potency and pharmacological activity, but also no liver toxicity and skin allergy. Tox data predicts that it has mutagenic potential, which may be the result of overreduction.
- Subjects
OLIVE; HYDROXYTYROSOL; HEPATOTOXICOLOGY; GASTROINTESTINAL system; FORECASTING
- Publication
Asian Journal of Traditional Medicines, 2023, Vol 18, Issue 2, p45
- ISSN
1817-4337
- Publication type
Article