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- Title
Improving the diagnosis of AATD with aid of serum protein electrophoresis: a prospective, multicentre, validation study.
- Authors
Scarlata, Simone; Ottaviani, Stefania; Villa, Alfredo; Baglioni, Stefano; Basile, Filomena; Annunziata, Anna; Santangelo, Simona; Francesconi, Maria; Arcoleo, Francesco; Balderacchi, Alice M.; Angeletti, Silvia; Magni, Sara; Corsico, Angelo G.; Ferrarotti, Ilaria
- Abstract
This document discusses the potential use of serum protein electrophoresis (SPE) as a screening tool for alpha-1 antitrypsin deficiency (AATD), a heritable condition that can lead to pulmonary and hepatic diseases. The study, conducted in four Italian hospitals, found that using the alpha1-globulin band in SPE can effectively detect AATD variants. The authors suggest that implementing SPE for population screening could lead to early intervention and improved outcomes for AATD patients. However, they note that SPE is not a diagnostic tool and cannot differentiate between different AATD variants or clinical phenotypes. Further research is needed to understand the clinical relevance of these findings.
- Subjects
BLOOD protein electrophoresis; DIAGNOSIS
- Publication
Clinical Chemistry & Laboratory Medicine, 2024, Vol 62, Issue 8, pe185
- ISSN
1434-6621
- Publication type
Letter
- DOI
10.1515/cclm-2024-0176