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- Title
Yolk sac tumour of the colon.
- Authors
Shah, Sejal S.; Chandan, Vishal S.
- Abstract
Objective: Extragonadal germ cell tumours are uncommon. We present the clinicopathologic features of a rare yolk sac tumour of the colon. Method: A 20-year old woman with known history of ulcerative colitis presented with acute abdominal pain. Imaging showed a 9-cm mass involving the region of cecum. No other abnormality was seen on imaging and the ovaries as well as the uterus appeared unremarkable. She underwent a right hemicolectomy. Data and Results: The sections from the mass centered in the cecum showed a cellular neoplasm with clear cytoplasm involving the entire colonic wall from the mucosa to the serosa. Admixtures of histologic patterns were seen represented by microcystic/reticular, pseudoglandular and solid patterns. Rare Schiller-Duval bodies were also present. Immunostains were performed and the tumour cells were positive for keratin AE1/AE3, SALL-4, alpha-fetoprotein, CD117, Glypican-3, and CDX2. Arginase-1 and PAX-8 stains were negative. BRG-1, INI-1 and the immunostains for mismatch repair enzymes were intact within the tumour cells. The overall morphology and the results of the stains support a diagnosis of yolk sac tumour. Additional clinical workup excluded the possibility of a metastasis and hence a diagnosis of primary yolk sac tumour of the colon was made. Conclusions: Extragonadal yolk sac tumour of the colon is extremely rare. Hence it is often not considered in the differential. The histologic variability of yolk sac tumour and its tendency to mimic somatic tumours pose diagnostic challenges. Its accurate diagnosis is essential for prognosis and appropriate clinical management.
- Subjects
ENDODERMAL sinus tumors; COLON tumors; ABDOMINAL pain; GASTROINTESTINAL tumors treatment; GASTROINTESTINAL disease diagnosis
- Publication
Canadian Journal of Pathology, 2018, Vol 10, p15
- ISSN
1918-915X
- Publication type
Article