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- Title
Autophagy modulation by PPAR-gamma agonists in obesity.
- Authors
Faghfouri, Amir Hossein; Khajebishak, Yaser; Payahoo, Laleh; Faghfuri, Elnaz
- Abstract
Introduction: Autophagy pathways are involved in the pathogenesis of some obesity related health problems. We aimed to investigate the possible mechanisms of action of peroxisome proliferator-activated receptor-gamma (PPAR-gamma) on the process of autophagy in obesity through narrating the effects of PPAR-gamma on autophagy in the non-obesity conditions. Methods: Current mechanistic systematic review aimed to explain the possible pathways through which PPAR-gamma agonists could affect autophagy in obesity. PubMed, Embase, Web of Science, and Scopus were searched up to October 2021. All clinical trials, animal and in vitro studies published in English were included. Results: As obesity is a nutrient sufficiency condition, autophagy process can be altered in obesity through AMP activated protein kinase (AMPK) inhibition. PPAR-gamma as the main modulator of adipogenesis process can be effective in the regulation of obesity related phenotypes. As well, it has been revealed that PPAR-gamma and its agonists can regulate autophagy in different normal or cancer cells. However, their effects on autophagy modulation in obesity have been investigated in the limited number of studies. Moreover, various studies have suggested the effects of autophagy regulation on the management of obesity and its associated complications. Conclusion: We raise the hypothesis that PPARgamma agonists can potentially affect autophagy pathways in obesity.
- Subjects
AUTOPHAGY; PPAR-gamma agonists; PROTEIN kinases; OBESITY; PHENOTYPES
- Publication
Journal of Nutrition, Fasting & Health, 2022, Vol 10, p272
- ISSN
2821-2746
- Publication type
Article