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- Title
Intrauterine perfusion immunotherapies in recurrent implantation failures: Systematic review.
- Authors
Cavalcante, Marcelo Borges; Cavalcante, Candice Torres de Melo Bezerra; Sarno, Manoel; Barini, Ricardo
- Abstract
Studies have investigated the gestational outcomes of new immunological therapies in the treatment of patients with recurrent implantation failure (RIF) in assisted reproductive technology (ART). The objective of this article is to assess the current state of evidence available in the literature on intrauterine perfusion immunotherapies in women undergoing ART treatments. By considering the guidelines of Preferred Reporting Items for Systematic Reviews and Meta‐Analysis (PRISMA), the authors performed systematic review by searching the databases of PubMed/MEDLINE and Scopus using the following key words: "recurrent implantation failure," "intrauterine infusion," "Platelet‐Rich Plasma (PRP)," "Peripheral Blood Mononuclear Cells (PBMC)," "Granulocyte Colony‐Stimulating Factor (G‐CSF)," and "Human Chorionic Gonadotropin (hCG)." The authors analyzed the indications and the impact of new immunological therapies with intrauterine infusions on the pregnancy outcomes of patients undergoing ART. PRP, PBMC, G‐CSF, and hCG were the four most used immunological therapies with intrauterine infusion. These new therapies appear to improve the results of ART treatments in cases of RIF. However, the small number of studies does not allow definitive conclusions about the effectiveness of these therapies.
- Subjects
META-analysis; CHORIONIC gonadotropins; PLATELET-rich plasma; INFUSION therapy; PERFUSION
- Publication
American Journal of Reproductive Immunology, 2020, Vol 83, Issue 6, p1
- ISSN
1046-7408
- Publication type
Article
- DOI
10.1111/aji.13242