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- Title
Do Immunocompromised Children Benefit from Having Surgical Lung Biopsy Performed?
- Authors
Goldstein, Gal; Keller, Nathan; Bilik, Ron; Bielorai, Bella; Toren, amos
- Abstract
Background: Surgical lung biopsy is considered a gold standard for the evaluation of pulmonary disease in immunocompromised children. However, in the literature, its accuracy and the rate of complications vary. Objective: We aimed to evaluate the yield of surgical lung biopsies in the management of persistent pulmonary findings in immunocompromised children. Methods: We performed a retrospective review of clinical records of immunocompromised children who underwent surgical lung biopsies, and evaluated the impact that preoperative factors had on outcomes. Results: Twenty-five patients underwent 27 surgical lung biopsies. The underlying immunodeficiency included allogeneic stem cell transplantation (n = 12), chemotherapy for solid tumors(n = 6), hematologic malignancy (n = 4), primary immunodeficiency (n = 4) and chronic steroid use (n = 1). Biopsies provided a specific histopathologic or microbiologic diagnosis in 10 cases (37%). No preoperative factor predicted a diagnostic biopsy. Five of the 27 biopsies werebeneficialfor the patients (18%). A major complication related to the procedure was reported for 1 biopsy (4%). Conclusions: We conclude that surgical lung biopsy in pediatric immunocompromised patients appears to be safe, but has a relatively low diagnostic yield and an even lower yield with regards to the benefit it provides. © 2014 S. Karger AG, Basel
- Subjects
IMMUNOCOMPROMISED patients; LUNG biopsy; LUNG disease diagnosis; MEDICAL records; BRONCHOALVEOLAR lavage; THORACIC surgery
- Publication
Acta Haematologica, 2015, Vol 133, Issue 2, p205
- ISSN
0001-5792
- Publication type
Article
- DOI
10.1159/000366262