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- Title
Association between CYP2C8 (rsl934951) Polymorphism and Bisphosphonate-Related Osteonecrosis of the Jaws in Patients on Bisphosphonate Therapy: A Meta-Analysis.
- Authors
Zhong, Da-Ni; Wu, Ji-Zhou; Li, Guo-Jian
- Abstract
Aims: Bisphosphonate-related osteonecrosis of the jaws (BONJ) is a severe complication in patients on bisphosphonate therapy. The study was conducted to verify the association between CYP2C8 (rs1934951) polymorphism and BONJ predisposition. Methods: The relative epidemiologic studies were identified in PubMed and Embase to conduct a meta-analysis using STATA. Results: In the pooled analysis with multiple cancer types, patients carrying the CYP2C8 rsl934951 AA or AG genotype showed no significantly increased BONJ susceptibility compared with those carrying the wild GG genotype [dominant: odds ratio (OR) = 2.05,95% confidence interval (CI) = 0.67-6.29, p = 0.209; recessive: OR = 1.88,95% CI = 0.23-15.6, p = 0.560; AG vs. GG: OR = 2.07, 95% CI = 0.80-5.32, p = 0.133, and AA vs. GG: OR = 1.34,95% CI = 0.48-3.74, p = 0.578], A significant association between AA and AG genotypes of CYP2C8 (rs1934951) and BONJ risk was found in the subgroup analysis of multiple myeloma (dominant: OR = 5.77, 95% CI = 1.21-27.63, p = 0.028; AG vs. GG: OR = 5.02,95% CI = 2.06-12.23, p = 0.001, and AA vs. GG: OR = 16.23, 95% CI = 1.72-78.7, p = 0.015). Conclusion: The results indicated that AA and AG genotypes of CYP2C8 (rs1934951) might be predictors for multiple myeloma patients at high risk to develop BONJ.
- Subjects
CYTOCHROME P-450; GENETIC polymorphisms; DIPHOSPHONATES; OSTEONECROSIS; JAW diseases; META-analysis; EPIDEMIOLOGY; THERAPEUTICS
- Publication
Acta Haematologica, 2013, Vol 129, Issue 2, p90
- ISSN
0001-5792
- Publication type
Article
- DOI
10.1159/000342120