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- Title
Effect of Imatinib Mesylate Combined with Granulocyte Colony-Stimulating Factor on Leukaemic Blast Cells Derived from Advanced-Stage Chronic Myelogenous Leukaemia Patients.
- Authors
Ota, Shuichi; Musashi, Manabu; Kondo, Keiichi; Toyoshima, Nobuyasu; Toubai, Tomomi; Onozawa, Masahiro; Mori, Akio; Hashino, Satoshi; Tanaka, Junji; Matsuno, Kazuhiko; Imamura, Masahiro; Asaka, Masahiro
- Abstract
Neutropenia is a severe adverse effect that can occur when treating patients with imatinib mesylate for advanced-stage chronic myelogenous leukaemia (CML). Therefore, we evaluated in vitro the combined effect of imatinib and granulocyte colony-stimulating factor (G-CSF) on proliferation and apoptosis of Bcr-Abl-expressing leukaemic cells to infer the safety of G-CSF administration. In KU812 and K562 cell lines, G-CSF neither stimulated their proliferation nor abolished the suppressive effect of imatinib. However, it stimulated the proliferation of blast cells in 2 out of the 5 cases with advanced-stage CML. These in vitro studies appear to provide data for the decision of G-CSF administration in combination with imatinib in the treatment of neutropenic patients with advanced-stage CML. Copyright © 2006 S. Karger AG, Basel
- Subjects
NEUTROPENIA; IMATINIB; ANTINEOPLASTIC agents; MYELOID leukemia; CELL proliferation; APOPTOSIS
- Publication
Acta Haematologica, 2006, Vol 116, Issue 1, p8
- ISSN
0001-5792
- Publication type
Article
- DOI
10.1159/000092342