We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
lincR-Ccr2-5′AS and THRIL as potential biomarkers of multiple sclerosis.
- Authors
Shaker, Olfat Gamil; Hassan, Amr; Mohammed, Asmaa Mohammed; Mohammed, Shereen Rashad
- Abstract
Background: Multiple sclerosis (MS) is a demyelinating disease affecting the central nervous system (CNS). Long non-coding RNAs (lncRNAs) were believed to play a role in the pathogenesis of neurological disorders including MS. lincR-Ccr2-5′AS is expressed in the T helper2 (Th2) lineage. TNF-α heterogeneous nuclear ribonucleoprotein L (THRIL) causes the induction of TNF-α and regulates innate immune response and inflammation. We investigated the expression of lincR-Ccr2-5′AS and THRIL in MS to clarify their association with MS risk and the clinical features. Results: LincR-Ccr2-5′AS was significantly downregulated in MS patients (fold change = 0.43±0.29, p = 0.03). The expression level was significantly low in patients with motor weakness and optic neuritis, patients with Expanded Disability Status Scale (EDSS) ≥5.5, and treatment-naïve patients. THRIL was significantly upregulated in MS patients (fold change = 6.18±2, p = 0.02). Its expression was significantly higher in patients with relapsing-remitting multiple sclerosis (RRMS), patients with motor weakness, patients with EDSS ≤5, and patients who received interferon. Conclusion: Our results showed the downregulation of lincR-Ccr2-5′AS and the upregulation of lncRNA THRIL in MS patients. This differential expression of both lncRNAs may have an important role in MS pathogenesis.
- Subjects
MYELIN oligodendrocyte glycoprotein; NUCLEOPROTEINS; MULTIPLE sclerosis; CENTRAL nervous system diseases; LINCRNA; OPTIC neuritis; DEMYELINATION
- Publication
Egyptian Journal of Medical Human Genetics, 2021, Vol 22, Issue 1, p1
- ISSN
1110-8630
- Publication type
Article
- DOI
10.1186/s43042-021-00151-2