We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
S100b Counteracts Neurodegeneration of Rat Cholinergic Neurons in Brain Slices after Oxygen-Glucose Deprivation.
- Authors
Serbinek, Daniela; Ullrich, Celine; Pirchl, Michael; Hochstrasser, Tanja; Schmidt-Kastner, Rainald; Humpel, Christian
- Abstract
Alzheimer's disease is a severe chronic neurodegenerative disorder characterized by beta-amyloid plaques, tau pathology, cerebrovascular damage, inflammation, reactive gliosis, and cell death of cholinergic neurons. The aim of the present study is to test whether the glia-derived molecule S100b can counteract neurodegeneration of cholinergic neurons after oxygen-glucose deprivation (OGD) in organotypic brain slices of basal nucleus of Meynert. Our data showed that 3 days of OGD induced a marked decrease of cholinergic neurons (60% of control), which could be counteracted by 50 μg/mL recombinant S100b. The effect was dose and time dependent. Application of nerve growth factor or fibroblast growth factor-2 was less protective. C-fos-like immunoreactivity was enhanced 3 hours afterOGDindicating metabolic stress.We conclude that S100b is a potent neuroprotective factor for cholinergic neurons during ischemic events.
- Subjects
ALZHEIMER'S disease; NEURODEGENERATION; NERVE growth factor; NEUROPROTECTIVE agents; CELL death; TISSUE slices
- Publication
Cardiovascular Psychiatry & Neurology, 2010, p1
- ISSN
2090-0163
- Publication type
Article
- DOI
10.1155/2010/106123