We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Hypervalent Iodine(III) Reagent Mediated Regioselective Cycloaddition of Aldoximes with Enaminones.
- Authors
Yoshimura, Akira; Jarvi, Melissa E.; Shea, Michael T.; Makitalo, Cody L.; Rohde, Gregory T.; Yusubov, Mekhman S.; Saito, Akio; Zhdankin, Viktor V.
- Abstract
An efficient oxidative cycloaddition of enaminones with nitrile oxides generated in situ from respective aldoximes using hypervalent iodine reagents has been developed. Reactions of various aldoximes with enaminones in the presence of [hydroxy(tosyloxy)iodo]benzene involved the regioselective cycloaddition reaction resulting in the formation of the 3,4‐disubstituted isoxazoles in moderate to good yields. Structures of several isoxazole products were confirmed by a single X‐ray crystallography.
- Subjects
HYPERVALENCE (Theoretical chemistry); ALDOXIMES; RING formation (Chemistry); IODINE; NITRILE oxides; REGIOSELECTIVITY (Chemistry); ISOXAZOLES
- Publication
European Journal of Organic Chemistry, 2019, Vol 2019, Issue 39, p6682
- ISSN
1434-193X
- Publication type
Article
- DOI
10.1002/ejoc.201901258