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- Title
Fluorinated Radicamine A and B: Synthesis and Glycosidase Inhibition.
- Authors
Li, Yi‐Xian; Iwaki, Ren; Kato, Atsushi; Jia, Yue‐Mei; Fleet, George W. J.; Zhao, Xuan; Xiao, Min; Yu, Chu‐Yi
- Abstract
Fluorinated derivatives of radicamine A and radicamine B have been synthesized from D-arabinose-derived cyclic nitrone. Structure-activity relationship studies showed that glycosidase inhibition of these fluorinated derivatives was significantly influenced by the position of the fluorine atom. C-7 or C-11 fluorination of the aromatic ring decreased α-glucosidase inhibition of the derivatives, whereas C-8 or C-10 fluorination preserved glycosidase inhibitory activities.
- Subjects
GLYCOSIDASES; CHEMICAL synthesis; FLUORINE; ARABINOSE; NITRONES; FLUORINATION
- Publication
European Journal of Organic Chemistry, 2016, Vol 2016, Issue 7, p1429
- ISSN
1434-193X
- Publication type
Article
- DOI
10.1002/ejoc.201501453