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- Title
Prevention of transient bacteraemia following impacted lower third molar surgery: A randomized triple‐blind controlled trial of chlorhexidine mouthrinse and amoxicillin.
- Authors
Suttapreyasri, Srisurang; Supatraviwat, Panu; Yingkajorn, Mingkwan; Laoisariyakul, Peerapong; Klaprabsuek, Aviga; Phattaraprueksa, Ornsarat; Pitthayajamrus, Sitthichai
- Abstract
Aim: Evaluate the efficacy of 0.3% chlorhexidine mouthwash (CHX) and 2‐g amoxicillin (AMX) on the prevalence and nature of transient bacteraemia after surgical removal of an impacted lower third molar. Materials and Methods: Thirty patients were assigned to either the CHX, AMX, or placebo groups (CTR) in a triple‐blind, randomized, placebo‐controlled trial. Blood was cultured and identified at three time points; baseline, 30 s and 15 min following flap incision. Samples were processed for using BACTECTM FX and then Matirx‐assisted laser desorption/ionization‐time of flight mass spectrometry for positive identification. Results: The prevalence of transient bacteraemia was 50% in the CTR group, and 10% each in the CHX and AMX groups. At 30 s, there was no difference in the prevalence of transient bacteraemia in the CHX (10%), AMX (10%) and CTR (30%) groups (p = 0.477). However, at 15 min, there was a statistically significant difference in the prevalence of bacteraemia between the CHX (0), AMX (10%) and CTR (40%) groups (p = 0.029). The majority of cultures yielded gram‐positive cocci. The most frequently isolated organisms were viridans streptococci and Actinomyces oris. Conclusion: 0.3% CHX is effective in preventing postoperative bacteraemia for at least 15min and may be considered as a prophylaxis antiseptic prior to thrid molar surgery. The trial was registered and approved by Thai Clinical Trails Registry Committee (TCTR20210531006).
- Subjects
THIRD molars; BACTEREMIA; ASEPSIS &; antisepsis; RANDOMIZED controlled trials; DENTAL extraction; AMOXICILLIN; CHLORHEXIDINE
- Publication
Oral Surgery (1752-2471), 2022, Vol 15, Issue 3, p277
- ISSN
1752-2471
- Publication type
Article
- DOI
10.1111/ors.12713