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- Title
Short stature and the risk of adiposity, insulin resistance, and type 2 diabetes in middle age: the Third National Health and Nutrition Examination Survey (NHANES III), 1988-1994.
- Authors
Asao K; Kao WHL; Baptiste-Roberts K; Bandeen-Roche K; Erlinger TP; Brancati FL; Asao, Keiko; Kao, W H Linda; Baptiste-Roberts, Kesha; Bandeen-Roche, Karen; Erlinger, Thomas P; Brancati, Frederick L
- Abstract
<bold>Objective: </bold>To investigate the association between stature-related measurements (height, leg length, and leg length-to-height ratio) and adiposity, insulin resistance, and glucose intolerance.<bold>Research Design and Methods: </bold>We conducted a cross-sectional analysis of a nationally representative sample of 7,424 adults aged 40-74 years, from the Third National Health and Nutrition Examination Survey (1988-1994). The main outcome measures were percent body fat, homeostasis model assessment of insulin resistance (HOMA-IR), and glucose intolerance based on the World Health Organization's 1985 criteria for an oral glucose tolerance test.<bold>Results: </bold>Shorter height and leg length, and lower leg length-to-height ratio, were associated with higher percent body fat, especially in women. Lower leg length-to-height ratio was associated with greater insulin resistance estimated by HOMA-IR. In multinomial regression models adjusting for potential confounders, including percent body fat, the relative prevalence of type 2 diabetes per 1-SD lower values in height, leg length, and leg length-to-height ratio were 1.10 (95% CI 0.94-0.29), 1.17 (0.98-1.39), and 1.19 (1.02-1.39), respectively.<bold>Conclusions: </bold>Our study supports the hypothesis that adult markers of prepubertal growth, especially leg length-to-height ratio, are associated with adiposity, insulin resistance, and type 2 diabetes in the general U.S. population.
- Publication
Diabetes Care, 2006, Vol 29, Issue 7, p1632
- ISSN
0149-5992
- Publication type
journal article
- DOI
10.2337/dc05-1997