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- Title
Phosphorylation of the regulatory subunit of smooth muscle protein phosphatase 1M at Thr850 induces its dissociation from myosin
- Authors
Velasco, Guillermo; Armstrong, Chris; Morrice, Nick; Frame, Sheelagh; Cohen, Philip
- Abstract
Rho kinase is known to control smooth muscle contractility by phosphorylating the 110 kDa myosin-targetting subunit (MYPT1) of the myosin-associated form of protein phosphatase 1 (PP1M). Phosphorylation of MYPT1 at Thr695 has previously been reported to inhibit the catalytic activity of PP1. Here, we show that the phosphorylation of Thr850 by Rho kinase dissociates PP1M from myosin, providing a second mechanism by which myosin phosphatase activity is inhibited.
- Subjects
REGULATION of muscle contraction; PHOSPHOPROTEIN phosphatases
- Publication
FEBS Letters, 2002, Vol 527, Issue 1-3, p101
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/S0014-5793(02)03175-7