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- Title
The expression of native and oxidized LDL receptors in brain microvessels is specifically enhanced by astrocytes-derived soluble factor(s)
- Authors
Lucarelli, Marco; Borrelli, Valeria; Fiori, Anna; Cucina, Alessandra; Granata, Filippo; Potenza, Rosa Luisa; Scarpa, Sigfrido; Cavallaro, Antonino; Strom, Roberto
- Abstract
Ex vivo rat brain microvessels express receptors for native as well as for oxidized low-density lipoproteins. In brain microvessels-derived endothelial cells, the expression levels of both receptors were enhanced by co-cultivation with rat astrocytes, even in the absence of actual contact between the two cell types, suggesting a soluble factor(s)-based mechanism of induction. No modulation effect could be evidenced in a heterologous cellular system. Since both receptors were found to be expressed also in astrocytes, these cells are likely to contribute substantially to the lipoprotein management at the blood–brain barrier and in the brain compartment.
- Subjects
LOW density lipoproteins; BLOOD-brain barrier; ASTROCYTES
- Publication
FEBS Letters, 2002, Vol 522, Issue 1-3, p19
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/S0014-5793(02)02857-0