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- Title
Smoking and polymorphisms of fucosyltransferase gene Le affect success of H. pylori eradication with lansoprazole, amoxicillin, and clarithromycin.
- Authors
Matsuo K; Hamajima N; Ikehara Y; Suzuki T; Nakamura T; Matsuura A; Tajima K; Tominaga S; Matsuo, K; Hamajima, N; Ikehara, Y; Suzuki, T; Nakamura, T; Matsuura, A; Tajima, K; Tominaga, S
- Abstract
Identification of factors influencing success of Helicobacter pylori (HP) eradication is important for clinical practice. We have prospectively conducted an HP eradication study in the Aichi Cancer Center with a total of 142 patients available for analysis. The overall success rate was 61.3% (95% confidence interval 52.7-69.3%). Smoking during the medication for eradication significantly decreased the success rate (42.9%), whereas smoking cessation during the treatment was associated with a similar rate as for non-smokers (66.7%). We also examined links between an eradication outcome and polymorphisms of Le, Se, IL1A, IL1B, IL1RN and MPO genes, but with one exception none showed any association. The non-functional le allele of Le polymorphisms, leading to decreased expression of Le(b) antigen to which HP attaches with adhesin, showed a beneficial effect for success. Although further clarification is necessary, our study indicated that smoking cessation and Le gene polymorphisms may affect the success rate of HP eradication.
- Publication
Epidemiology & Infection, 2003, Vol 130, Issue 2, p227
- ISSN
0950-2688
- Publication type
journal article
- DOI
10.1017/s0950268802008129