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- Title
In vitro activity of antifungals in combination with essential oils against the oomycete Pythium insidiosum.
- Authors
Valente, J.S.; Fonseca, A.O.S.; Denardi, L.B.; Dal Ben, V.S.; Maia Filho, F.S.; Zambrano, C.G.; Braga, C.Q.; Alves, S.H.; Botton, S.A.; Brayer Pereira, D.I.
- Abstract
Aims The aim of this study was to investigate the in vitro susceptibility of Pythium insidiosum to combinations of the antifungal drugs terbinafine or itraconazole with Melaleuca alternifolia, Mentha piperita and Origanum vulgare essential oils ( EOs). Methods and Results In vitro combinations of antifungal drugs with EOs were evaluated by checkerboard microdilution method against 20 Brazilian isolates of P. insidiosum. The tests were performed according to protocol M38-A2, and the interpretation of each combination result was based on the values of the fractional inhibitory concentration index. The combinations of itraconazole with EOs presented prominent synergistic effects against P. insidiosum isolates, and no antagonism was observed with these combinations. However, the combinations of terbinafine with EOs resulted in indifferent or antagonistic effects. Conclusions The combination of plant-derived bioactive compounds with antifungal drugs may be an alternative therapy for the control of infections caused by P. insidiosum. Studies of new therapeutic protocols involving these proposed combinations are needed. Significance and Impact of the Study The antimicrobial combinations using EOs with terbinafine or itraconazole can be an attractive therapeutic option for controlling P. insidiosum infections.
- Subjects
TERBINAFINE; ANTIFUNGAL agents; PEPPERMINT oil; MELALEUCA alternifolia; OREGANO; ESSENTIAL oils; OOMYCETES; AZOLES
- Publication
Journal of Applied Microbiology, 2016, Vol 121, Issue 4, p998
- ISSN
1364-5072
- Publication type
Article
- DOI
10.1111/jam.13234