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- Title
Transcriptional and post-transcriptional regulation of the genes encoding the small GTPases RhoA, RhoB, and RhoC: implications for the pathogenesis of human diseases.
- Authors
Nomikou, Eirini; Livitsanou, Melina; Stournaras, Christos; Kardassis, Dimitris
- Abstract
Rho GTPases are highly conserved proteins that play critical roles in many cellular processes including actin dynamics, vesicular trafficking, gene transcription, cell-cycle progression, and cell adhesion. The main mode of regulation of Rho GTPases is through guanine nucleotide binding (cycling between an active GTP-bound form and an inactive GDP-bound form), but transcriptional, post-transcriptional, and post-translational modes of Rho regulation have also been described. In the present review, we summarize recent progress on the mechanisms that control the expression of the three members of the Rho-like subfamily (RhoA, RhoB, and RhoC) at the level of gene transcription as well as their post-transcriptional regulation by microRNAs. We also discuss the progress made in deciphering the mechanisms of cross-talk between Rho proteins and the transforming growth factor β signaling pathway and their implications for the pathogenesis of human diseases such as cancer metastasis and fibrosis.
- Subjects
RHO factor; GENETIC transcription; GUANOSINE triphosphatase; DISEASE progression; RNA interference; CELL adhesion
- Publication
Cellular & Molecular Life Sciences, 2018, Vol 75, Issue 12, p2111
- ISSN
1420-682X
- Publication type
Article
- DOI
10.1007/s00018-018-2787-y