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- Title
Is hepatic lipogenesis fundamental for NAFLD/NASH? A focus on the nuclear receptor coactivator PGC-1β.
- Authors
Ducheix, Simon; Vegliante, Maria; Villani, Gaetano; Napoli, Nicola; Sabbà, Carlo; Moschetta, Antonio
- Abstract
Non-alcoholic fatty liver diseases are the hepatic manifestation of metabolic syndrome. According to the classical pattern of NAFLD progression, de novo fatty acid synthesis has been incriminated in NAFLD progression. However, this hypothesis has been challenged by the re-evaluation of NAFLD development mechanisms together with the description of the role of lipogenic genes in NAFLD and with the recent observation that PGC-1β, a nuclear receptor/transcription factor coactivator involved in the transcriptional regulation of lipogenesis, displays protective effects against NAFLD/NASH progression. In this review, we focus on the implication of lipogenesis and triglycerides synthesis on the development of non-alcoholic fatty liver diseases and discuss the involvement of these pathways in the protective role of PGC-1β toward these hepatic manifestations.
- Subjects
FATTY liver; NUCLEAR receptors (Biochemistry); HEPATIC manifestations of general diseases; LIPID synthesis; TRIGLYCERIDES; DISEASE risk factors
- Publication
Cellular & Molecular Life Sciences, 2016, Vol 73, Issue 20, p3809
- ISSN
1420-682X
- Publication type
Article
- DOI
10.1007/s00018-016-2331-x