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- Title
The Biotransformed Metabolite Profiles in Blood after Intravenous Administration of Dehydrocholic Acid.
- Authors
Yoneda, Masashi; Makino, Isao; Tamasawa, Naoki; Takebe, Kazuo; Sakuraba, Kiyoshi; Goto, Junichi; Nambara, Toshio
- Abstract
One gram of dehydrocholic acid was injected intravenously into two patients with percutaneous transhepatic cholangial drainage, and the biotransformed metabolites profiles over a 120-min period in serum and bile were analyzed. In serum unconjugated 3α-hydroxy-7,12- dioxo-cholanoic acid (3α-OH-7, 12-OXO) acid was markedly increased after the injection of dehydrocholic acid, and reached about 80 µM within 30 min. On the other hand, conjugated 3α, 7α-dihydroxy-12-oxo-cholanoic acid (3α, 7α-OH-12-OXO) was consecutively increased with lag time to an elevation of 3α-OH-7, 12-OXO. In bile, the major constituent of metabolites was conjugated 3α, 7α-OH-12-OXO (more than 90% of the excreted metabolites), while conjugated 3α-OH-7, 12-OXO was detected as minor constituent. Therefore, between bile and serum, there was great difference in biotransformed metabolites profiles. The mechanism of elevation of unconjugated 3α-OH-7, 12-OXO in serum remains obscure, but this new finding raised a question as to whether organ-reducing 3-keto group of dehydrocholic acid is restricted to the liver.
- Subjects
METABOLITES; SERUM; BILE; BLOOD; LIVER diseases
- Publication
American Journal of Gastroenterology (Springer Nature), 1989, Vol 84, Issue 3, p290
- ISSN
0002-9270
- Publication type
Article