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- Title
The Effects of Endoscopic Sclerotherapy Combined with Transhepatic Variceal Obliteration on Portal Hemodynamics.
- Authors
Ohnishi, Kunihiko; Nakata, Hisashi; Terabayashi, Hidetaka; Tanaka, Hideo; Tsunoda, Takafumi; Iida, Shinji; Nomura, Fumio
- Abstract
We studied the effects of endoscopic sclerotherapy with transhepatic variceal obliteration on portal hemodynamics in 20 patients with cirrhosis (six with a spontaneous splenorenal shunt and 14 without it). Portal venous flow 1 month after combined therapy (measured by pulsed Doppler flowmeter) was significantly increased compared with that before therapy (n = 20, 843 ± 339 vs. 669 ± 253 ml/min., <em>p</em> < 0.001). Portal vein catheterization and portal venous flow measurement were repeated 18 months after therapy in eight patients without a splenorenal shunt before therapy and in two patients with a splenorenal shunt before therapy. Two of the former developed a splenorenal shunt. In these 10 patients, portal venous flow before, one month, and 18 months after therapy was 617 ± 219, 784 ± 227, and 720 ± 224 ml/min., respectively, and in 8 of 10 patients the portal venous flow at 18 months remained similar to the values at one month. Portal vein pressures were not significantly elevated 18 months after therapy (35.4 ± 6.4 <em>vs.</em> 33.6 ± 5.1 cm H2O) and the mean portal vein pressure change was 2.75 cm H2O (range -6 to +7.5 cm H2O). To summarize, portal venous flow was significantly increased one month after combined sclerotherapy in cirrhotics, the portal venous flow at 18 months remained similar to the values at 1 month in most patients, and the change in portal vein pressure after therapy was small.
- Subjects
SCLEROTHERAPY; PORTAL vein; HEMODYNAMICS; CIRRHOSIS of the liver; BLOOD flow; PATIENTS
- Publication
American Journal of Gastroenterology (Springer Nature), 1987, Vol 82, Issue 11, p1138
- ISSN
0002-9270
- Publication type
Article