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- Title
Genetic linkage analysis applied to unaffected women from families with breast cancer can discriminate high- from low-risk individuals.
- Authors
Porter, D. E.; Steel, C. M.; Cohen, B. B.; Wallace, M. R.; Carothers, A.; Chetty, U.; Carter, D. C.
- Abstract
Up to 20 per cent of cases of breast cancer diagnosed in women under the age of 45 years may be caused by an autosomal dominant gene. A present difficulty is differentiation of mutation carriers from nonmutation carriers in high-risk families. Genetic linkage analysis has been used to localize a susceptibility gene (BRCA1) on chromosome 17q12-21 between markers 42D6 and MFD 188, a region 5-10 million base pairs in length. Odds in favour of linkage to this region were greater than 100 000: 1 in 15 families with breast cancer. In eight families in which the probability of linkage was above 75 (range 79·2-99·9) per cent, 19 women were identified who were at high lifetime risk of breast cancer (range 80·6-87·2 per cent) and 37 whose risk was similar to that for the general population (range 9·8-16·4 per cent). Genetic risk prediction of this kind may enable high-risk screening clinic resources to be concentrated on those most likely to benefit.
- Publication
British Journal of Surgery, 1993, Vol 80, Issue 11, p1381
- ISSN
0007-1323
- Publication type
Article
- DOI
10.1002/bjs.1800801108