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- Title
Alterations in Plasma Lipid Profiles Associated with Melanoma and Therapy Resistance.
- Authors
Dei Cas, Michele; Ciniselli, Chiara Maura; Vergani, Elisabetta; Ciusani, Emilio; Aloisi, Mariachiara; Duroni, Valeria; Verderio, Paolo; Ghidoni, Riccardo; Paroni, Rita; Perego, Paola; Beretta, Giovanni Luca; Gatti, Laura; Rodolfo, Monica
- Abstract
Dysfunctions of lipid metabolism are associated with tumor progression and treatment resistance of cutaneous melanoma. BRAF/MEK inhibitor resistance is linked to alterations of melanoma lipid pathways. We evaluated whether a specific lipid pattern characterizes plasma from melanoma patients and their response to therapy. Plasma samples from patients and controls were analyzed for FASN and DHCR24 levels and lipidomic profiles. FASN and DHCR24 expression resulted in association with disease condition and related to plasma cholesterol and triglycerides in patients at different disease stages (n = 144) as compared to controls (n = 115). Untargeted lipidomics in plasma (n = 40) from advanced disease patients and controls revealed altered levels of different lipids, including fatty acid derivatives and sphingolipids. Targeted lipidomics identified higher levels of dihydroceramides, ceramides, sphingomyelins, ganglioside GM3, sphingosine, sphingosine-1-phosphate, and dihydrosphingosine, saturated and unsaturated fatty acids. When melanoma patients were stratified based on a long/short-term clinical response to kinase inhibitors, differences in plasma levels were shown for saturated fatty acids (FA 16:0, FA18:0) and oleic acid (FA18:1). Our results associated altered levels of selected lipid species in plasma of melanoma patients with a more favorable prognosis. Although obtained in a small cohort, these results pave the way to lipidomic profiling for melanoma patient stratification.
- Subjects
BLOOD lipids; SATURATED fatty acids; UNSATURATED fatty acids; FATTY acid derivatives; LIPID metabolism; LIPIDS
- Publication
International Journal of Molecular Sciences, 2024, Vol 25, Issue 3, p1558
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms25031558