We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Pathophysiology of Atrial Fibrillation and Approach to Therapy in Subjects Less than 60 Years Old.
- Authors
Curcio, Antonio; Scalise, Rosa; Indolfi, Ciro
- Abstract
Atrial fibrillation (AF) is an arrhythmia that affects the left atrium, cardiac function, and the patients' survival rate. Due to empowered diagnostics, it has become increasingly recognized among young individuals as well, in whom it is influenced by a complex interplay of autoimmune, inflammatory, and electrophysiological mechanisms. Deepening our understanding of these mechanisms could contribute to improving AF management and treatment. Inflammation is a complexly regulated process, with interactions among various immune cell types, signaling molecules, and complement components. Addressing circulating antibodies and designing specific autoantibodies are promising therapeutic options. In cardiomyopathies or channelopathies, the first manifestation could be paroxysmal AF; persistent forms tend not to respond to antiarrhythmic drugs in these conditions. Further research, both in vitro and in vivo, on the use of genomic biotechnology could lead to new therapeutic approaches. Additional triggers that can be encountered in AF patients below 60 years of age are systemic hypertension, overweight, diabetes, and alcohol abuse. The aims of this review are to briefly report evidence from basic science and results of clinical studies that might explain the juvenile burden of the most encountered sustained supraventricular tachyarrhythmias in the general population.
- Subjects
ATRIAL fibrillation; PATHOLOGICAL physiology; COMPLEMENT (Immunology); LEFT heart atrium; MYOCARDIAL depressants; ARRHYTHMIA; ATRIAL flutter
- Publication
International Journal of Molecular Sciences, 2024, Vol 25, Issue 2, p758
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms25020758