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- Title
Topical Administration of a Marine Oil Rich in Pro-Resolving Lipid Mediators Accelerates Wound Healing in Diabetic db/db Mice through Angiogenesis and Macrophage Polarization.
- Authors
Ontoria-Oviedo, Imelda; Amaro-Prellezo, Elena; Castellano, Delia; Venegas-Venegas, Elena; González-Santos, Fernando; Ruiz-Saurí, Amparo; Pelacho, Beatriz; Prósper, Felipe; Pérez del Caz, María Dolores; Sepúlveda, Pilar
- Abstract
Impaired wound healing in patients with type 2 diabetes (DM2) is characterized by chronic inflammation, which delays wound closure. Specialized pro-resolving lipid mediators (SPMs) are bioactive molecules produced from essential polyunsaturated fatty acids (PUFAs), principally omega-3 docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA). SPMs are potent regulators of inflammation and have been used to suppress chronic inflammation in peripheral artery disease, non-alcoholic fatty liver disease, and central nervous system syndromes. LIPINOVA® is a commercially available safe-grade nutritional supplement made from a fractionated marine lipid concentrate derived from anchovy and sardine oil that is rich in SPMs and EPA, as well as DHA precursors. Here, we assessed the effect of LIPINOVA® in wound dressing applications. LIPINOVA® showed biocompatibility with keratinocytes and fibroblasts, reduced the abundance of pro-inflammatory macrophages (Mφ1), and promoted in vitro wound closure. Daily application of the marine oil to open wounds made by punch biopsy in db/db mice promoted wound closure by accelerating the resolution of inflammation, inducing neoangiogenesis and Mφ1/Mφ2 macrophage polarization. In conclusion, LIPINOVA® displays pro-resolutive properties and could be exploited as a therapeutic agent for the treatment of diabetic ulcers.
- Subjects
FISH oils; TOPICAL drug administration; HEALING; ESSENTIAL fatty acids; NON-alcoholic fatty liver disease; UNSATURATED fatty acids
- Publication
International Journal of Molecular Sciences, 2022, Vol 23, Issue 17, p9918
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms23179918