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- Title
p53 Controls Meiotic Prophase Progression and Crossover Formation.
- Authors
Marcet-Ortega, Marina; Maldonado-Linares, Andros; López-Panadés, Maria; Roig, Ignasi
- Abstract
Meiosis initiates with the formation of double strand breaks (DSBs) throughout the genome. To avoid genomic instability, these DSBs need to be correctly repaired by homologous recombination. Surveillance mechanisms involving the DNA damage response (DDR) pathway ATM-CHK2-p53 can detect the persistence of unrepaired DBSs and activate the recombination-dependent arrest at the pachytene stage. However, a complete understanding of p53 functions under normal physiological conditions remains lacking. Here, we report a detailed analysis of the p53 role during meiotic prophase in mice spermatocytes. We show that the absence of p53 regulates prophase progression by slowing down the pachytene stage when the recombination-dependent arrest occurs. Furthermore, our results show that p53 is necessary for proper crossover (CO) formation and localization. Our study contributes to a deeper understanding of p53 roles during the meiotic prophase.
- Subjects
MEIOSIS; DNA damage; ARREST
- Publication
International Journal of Molecular Sciences, 2022, Vol 23, Issue 17, p9818
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms23179818