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- Title
Role of miRNAs in Human T Cell Leukemia Virus Type 1 Induced T Cell Leukemia: A Literature Review and Bioinformatics Approach.
- Authors
Machado, Caio Bezerra; da Cunha, Leidivan Sousa; Maués, Jersey Heitor da Silva; Pessoa, Flávia Melo Cunha de Pinho; de Oliveira, Marcelo Braga; Ribeiro, Rodrigo Monteiro; Lopes, Germison Silva; de Moraes Filho, Manoel Odorico; de Moraes, Maria Elisabete Amaral; Khayat, André Salim; Moreira-Nunes, Caroline Aquino
- Abstract
Human T cell leukemia virus type 1 (HTLV-1) was identified as the first pathogenic human retrovirus and is estimated to infect 5 to 10 million individuals worldwide. Unlike other retroviruses, there is no effective therapy to prevent the onset of the most alarming diseases caused by HTLV-1, and the more severe cases manifest as the malignant phenotype of adult T cell leukemia (ATL). MicroRNA (miRNA) dysfunction is a common feature of leukemogenesis, and it is no different in ATL cases. Therefore, we sought to analyze studies that reported deregulated miRNA expression in HTLV-1 infected cells and patients' samples to understand how this deregulation could induce malignancy. Through in silico analysis, we identified 12 miRNAs that stood out in the prediction of targets, and we performed functional annotation of the genes linked to these 12 miRNAs that appeared to have a major biological interaction. A total of 90 genes were enriched in 14 KEGG pathways with significant values, including TP53, WNT, MAPK, TGF-β, and Ras signaling pathways. These miRNAs and gene interactions are discussed in further detail for elucidation of how they may act as probable drivers for ATL onset, and while our data provide solid starting points for comprehension of miRNAs' roles in HTLV-1 infection, continuous effort in oncologic research is still needed to improve our understanding of HTLV-1 induced leukemia.
- Subjects
HTLV; MICRORNA; COMPREHENSION in children
- Publication
International Journal of Molecular Sciences, 2022, Vol 23, Issue 10, p5486
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms23105486