We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Urinary Protein and Peptide Markers in Chronic Kidney Disease.
- Authors
Chebotareva, Natalia; Vinogradov, Anatoliy; McDonnell, Valerie; Zakharova, Natalia V.; Indeykina, Maria I.; Moiseev, Sergey; Nikolaev, Evgeny N.; Kononikhin, Alexey S.
- Abstract
Chronic kidney disease (CKD) is a non-specific type of kidney disease that causes a gradual decline in kidney function (from months to years). CKD is a significant risk factor for death, cardiovascular disease, and end-stage renal disease. CKDs of different origins may have the same clinical and laboratory manifestations but different progression rates, which requires early diagnosis to determine. This review focuses on protein/peptide biomarkers of the leading causes of CKD: diabetic nephropathy, IgA nephropathy, lupus nephritis, focal segmental glomerulosclerosis, and membranous nephropathy. Mass spectrometry (MS) approaches provided the most information about urinary peptide and protein contents in different nephropathies. New analytical approaches allow urinary proteomic–peptide profiles to be used as early non-invasive diagnostic tools for specific morphological forms of kidney disease and may become a safe alternative to renal biopsy. MS studies of the key pathogenetic mechanisms of renal disease progression may also contribute to developing new approaches for targeted therapy.
- Subjects
CHRONIC kidney failure; CARDIOVASCULAR diseases; SYMPTOMS; DIABETIC nephropathies; FOCAL segmental glomerulosclerosis; CIRCULATING tumor DNA
- Publication
International Journal of Molecular Sciences, 2021, Vol 22, Issue 22, p12123
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms222212123