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- Title
Effects of Baccharin Isolated from Brazilian Green Propolis on Adipocyte Differentiation and Hyperglycemia in ob/ob Diabetic Mice.
- Authors
Watanabe, Akio; de Almeida, Marília Oliveira; Deguchi, Yusuke; Kozuka, Ryuzo; Arruda, Caroline; Berretta, Andresa Aparecida; Bastos, Jairo Kenupp; Woo, Je-Tae; Yonezawa, Takayuki
- Abstract
Propolis is a honeybee product with various biological activities, including antidiabetic effects. We previously reported that artepillin C, a prenylated cinnamic acid derivative isolated from Brazilian green propolis, acts as a peroxisome proliferator-activated receptor γ (PPARγ) ligand and promotes adipocyte differentiation. In this study, we examined the effect of baccharin, another major component of Brazilian green propolis, on adipocyte differentiation. The treatment of mouse 3T3-L1 preadipocytes with baccharin resulted in increased lipid accumulation, cellular triglyceride levels, glycerol-3-phosphate dehydrogenase activity, and glucose uptake. The mRNA expression levels of PPARγ and its target genes were also increased by baccharin treatment. Furthermore, baccharin enhanced PPARγ-dependent luciferase activity, suggesting that baccharin promotes adipocyte differentiation via PPARγ activation. In diabetic ob/ob mice, intraperitoneal administration of 50 mg/kg baccharin significantly improved blood glucose levels. Our results suggest that baccharin has a hypoglycemic effect on glucose metabolic disorders, such as type 2 diabetes mellitus.
- Subjects
FAT cells; HYPERGLYCEMIA; PROPOLIS; PEROXISOME proliferator-activated receptors; TYPE 2 diabetes; CINNAMIC acid derivatives; BLOOD sugar
- Publication
International Journal of Molecular Sciences, 2021, Vol 22, Issue 13, p6954
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms22136954