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- Title
Antibacterial and Antibiofilm Activity and Mode of Action of Magainin 2 against Drug-Resistant Acinetobacter baumannii.
- Authors
Kim, Min Kyung; Kang, Na Hee; Ko, Su Jin; Park, Jonggwan; Park, Eunji; Shin, Dong Won; Kim, Seo Hyun; Lee, Seung A.; Lee, Ji In; Lee, Seung Hyun; Ha, Eun Gi; Jeon, Seung Hun; Park, Yoonkyung
- Abstract
Antimicrobial peptides (AMPs) are promising therapeutic agents for treating antibiotic-resistant bacterial infections. Previous studies showed that magainin 2 (isolated from African clawed fogs Xenopus laevis) has antimicrobial activity against gram-positive and gram-negative bacteria. The present study was conducted to investigate the antibacterial activity of magainin 2 against Acinetobacter baumannii. Magainin 2 showed excellent antibacterial activity against A. baumannii strains and high stability at physiological salt concentrations. This peptide was not cytotoxic towards HaCaT cells and showed no hemolytic activity. Biofilm inhibition and elimination were significantly induced in all A. baumannii strains exposed to magainin 2. We confirmed the mechanism of magainin 2 on the bacterial outer and inner membranes. Collectively, these results suggest that magainin 2 is an effective antimicrobial and antibiofilm agent against A. baumannii strains.
- Subjects
DRUG resistance; ACINETOBACTER baumannii; ANTIBACTERIAL agents; MAGAININS; PEPTIDE antibiotics
- Publication
International Journal of Molecular Sciences, 2018, Vol 19, Issue 10, p3041
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms19103041