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- Title
SOX7 Target Genes and Their Contribution to Its Tumor Suppressive Function.
- Authors
Zhang, Yumeng; Stovall, Daniel B.; Wan, Meimei; Zhang, Qiang; Chou, Jeff W.; Li, Dangdang; Sui, Guangchao
- Abstract
SOX7 is a transcription factor and acts as a tumor suppressor, but its target genes in cancers are poorly explored. We revealed SOX7-mediated gene expression profile in breast cancer cells using microarray chips and discovered multiple altered signaling pathways. When combinatorially analyzing the microarray data with a gene array dataset from 759 breast cancer patients, we identified four genes as potential targets of SOX7 and validated them by quantitative PCR and chromatin immunoprecipitation assays. Among these four genes, we determined that SOX7-activated <italic>SPRY1</italic> and <italic>SLIT2</italic>, and SOX7-repressed <italic>TRIB3</italic> and <italic>MTHFD2</italic> could all differentially contribute to SOX7-mediated tumor suppression. Overall, we identified multiple cancer-related pathways mediated by SOX7 and for the first time revealed SOX7-regulated target genes in a cancer-relevant context.
- Subjects
TUMOR suppressor proteins; GENE expression; CELL-mediated cytotoxicity; CHROMATIN; IMMUNOPRECIPITATION
- Publication
International Journal of Molecular Sciences, 2018, Vol 19, Issue 5, p1451
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms19051451