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- Title
Norcembranoidal Diterpenes from the Cultured-Type Octocoral Sinularia numerosa.
- Authors
Wu-Fu Chen; Chen-Ting Yin; Ching-Hsiao Cheng; Mei-Chin Lu; Lee-Shing Fang; Wei-Hsien Wang; Zhi-Hong Wen; Jih-Jung Chen; Yang-Chang Wu; Ping-Jyun Sung
- Abstract
A known norcembranoidal diterpene, 5-episinuleptolide (1), along with a new analogue, 4a-hydroxy-5-episinuleptolide (2), were isolated from a cultured-type soft coral Sinularia numerosa. The structures of 1 and 2 were elucidated on the basis of spectroscopic methods and by comparison of the data with those of the related metabolites. Cytotoxicity of metabolites 1 and 2 against a panel of tumor cells is also described. Compound 2 exhibited moderate cytotoxicity toward CCRF-CEM cells with an IC50 value 4.21 µg/mL. Preliminary SAR (structure activity relationship) information was obtained from these two compounds.
- Subjects
OCTOCORALLIA; DITERPENES; ALCYONIIDAE; CELL-mediated cytotoxicity; STRUCTURE-activity relationships; METABOLITES; CANCER cells
- Publication
International Journal of Molecular Sciences, 2015, Vol 16, Issue 2, p3298
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms16023298